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Ageless Xtra & Xperia

A naturopathic physicians perspective – Neil Tessler MD,DHANP

The Following article is myown personal research. It is not meant to suggest a cure, diagnosis or treatment for any condition, but represents a careful scan of research supported potential benefits of the individual ingredients of Ageless Xtra and Xperia (higher potency, no sucralose,five more ingredients). This document has no official or unofficial acknowledgement from Univera at this time, and is purely for educational and research purposes only.
In my office, almost daily, sometimes several times a day,someone phones or writes to request more Ageless Xtra orXperia because of the overall benefits they are noticing for themselves or a family member. In twenty-five years practice, I’ve never carried an item in my naturopathic pharmacy that has been so eagerly appreciated by so many of my patients. As a result I’ve put together the following discussion of some of the individual ingredients. Ageless Xtra and Xperia address a number of the common causes and effects of aging by supporting repair and preventing damage. It does this by nourishing, restoring, fortifying/protecting and vitalizing basic functional units of the cell. On the basis of traditional usage, supported by wide ranging research, including Univera’s own, third party research studies of its products, Ageless Xtra and Xperiamay help:
1) Improve mental clarity and focus
2) Enhance cellular energy
3) Aid in joint comfort and flexibility
4) Help the body’s management of stress
5) Provide an exceptionally rich source of diverse antioxidants, as well as substances that activate natural anti-oxidant activity in the body.
A few research based potential benefits of the individual ingredients:
1) Supports improved blood lipid profile
2) Prevention of atherosclerosis
3) Heart and vascular protection
4) Prevention of cellular mutation
5) Improved stamina in both physical and mental performance
6) Improved healing time from injury
7) Enhanced nutrient absorption
8) Enhanced connective tissue/protein repair
9) Improved blood sugar metabolism
10) Anti-bacterial, anti-viral activity
Let’s review some of the specific ingredients and their potential benefits as derived from scientific literature.
Cordyceps Sinensis Cordyceps is one of the supreme anti-aging plants and comes from the fungi family. Cordyceps is a fungus that in nature lives on the larva of a particular species of moth in Tibet. It is now grown in specialized media that maximize its medicinal components. According to available research studies, the following effects of Cordyceps have been indicated:
It can reduce total cholesterol and triglycerides, lower blood viscosity(mild blood thinning), enhance the efficient use of oxygen,improve glucose metabolism by increasing insulin sensitivity, improve libido, enable weight loss, stabilize heart rhythm, increase the body’s ability to scavenge free radicals, increase overall vitality, and reduce the symptoms of several age related respiratory and kidney
disorders.Cordyceps increases ATP production (in animal model research). ATP serves as the primary energy currency of the cell and is the most widely distributed high-energy compound in the body. Several ingredients in Xperia support the healthy function of Kreb’s Citric Acid(cellular respiration cycle), the basic energy creating process of the cell which produces ATP as a by product.Cordyceps activates Superoxide Dismutase (SOD) one of the most important free radical scavenging molecules. SOD dramatically decreases with age. Cordyceps is therefore a significant anti-oxidant.Cordyceps also helps inhibit specific brain chemicals associated with age related conditions impacting mental function.
Rhodiola crenulata There are several medicinal species of Rhodiola. Thisspecies is also found in the mountains of Tibet and SouthWestern China. It can be a valuable in reducing the effects of stress on the body.Research indicates Rhodiola enhances physical and mental work performance. It can be of value in sleep difficulties, poor appetite, irritability, hypertension, headaches and fatigue. Rhodiola has been shown to enhance the transport of tryptophan and 5-HTP (serotonin precursors), as well as helping to reduce the degradation of other mood-elevating neurotransmitters in the brain. Besides improving resistance to physical and emotional stress, Rhodiola increases stamina in athletic and intellectual performance. In athletes, Rhodiola decreases recovery time. Rhodiola increases focus, learning and memory. It also improves the quantity and quality of mental work. Rhodiola has been shown to promote higherlevels of ATP and Creatine Phosphate, providing more of the energy required for physical exertion throughout the day. Rhodiola is also cardio-protective, working against stress induced heart damage. Sometimes people taking Xperia report feeling jittery as if they had coffee. Rhodiola is likely the responsible agen tas some individuals may feel overly activated, jittery, or agitated. If this occurs, then a smaller dose with very gradual increases may be needed. If used late in the day,Rhodiola can, for some people, interfere with sleep or cause vivid dreams during the first few weeks of use.
Ginkgo Biloba Ginkgo biloba is the oldest tree species that exists having a two hundred and fifty million year history. Ginkgo leaf is the source of its values. It improves blood flow(including microcirculation in small capillaries) to most tissues and organs and has potent anti-oxidant value. Ginkgo is widely touted as a “brain herb.” Ginkgo can improve attention, learning and memory in healthy individuals.In addition, Ginkgo is sometimes used preventively because it may delay the onset of Alzheimer’s in someone who is at risk for this type of dementia (for example where there is family history).Ginkgo may stop or reduce some retinal problems by increasing circulation to the eyes. Retinal damage has a number of potential causes, including diabetes and macular degeneration. Studies suggest that Gingko may help preserve vision in those with macular degeneration.A clinical study found that Ginkgo extract reduces the effects of menopause on thinking and memory. Ornithine Alpha Keto-glutarate Alpha Keto-glutarate is a rate-limiting step in the Kreb’s cellular respiration cycle that produces ATP, the body’sprimary energy currency. As we age, Alpha Keto-glutarate diminishes, therefore reducing the capacity to produce ATP.It is therefore critical in maintaining the vitality of the energy creating process.Alpha Keto-glutarate increases muscle protein synthesis and decreases protein catabolism or breakdown. It also speeds wound healing.In addition, Alpha Keto-glutarate in combination with ornithine (OKG) dramatically increases the synthesis of amino acids arginine, proline and polyamines, which play key roles in the body’s response to trauma. Therefore, it can counteract trauma-induced immune disturbance.OKG also helps support our most important protein building hormones, including human growth hormone (HGH), insulin like growth factor, and insulin. It has been documented that trauma, stress, and aging cause a dramatic decrease inthe level and function of these important hormones. Among OKG’s effects in the body is the ability to simultaneously increase all these important anabolic hormones.
Protectin This is a patented, propriety botanical product, unique to the
Univera line. Research demonstrates its safe yet potentability to gently down-regulate the three major inflammatory pathways COX1, COX 2 and 5LO.
Maxcell This is another propriety botanical product unique to the
Univera line that has been shown to dramatically increase nutrient absorption. It has also been shown to stimulate cellular renewal, as well as amplifying the effects of other nutrients and enhancing immune activity.
Seroctin/Serenix Seroctin is an alkaloid (6-MBOA) derived from young cornshoots. Findings to date suggest its value in improved mood, enhanced memory and decreased anxiety. It also appears to help improve sleep quality. Seroctin increases the production of serotonin and melatonin. Some finding in rodent research suggest that seroctin may also increase libido and reduce appetite. Too much seroctin may induce the need for sleep.
Alpha-Lipoic Acid Alpha lipoic acid is a powerful, natural antioxidant becoming recognized as having unique benefits in the therapy and prevention of a broad range of conditions. In addition to its antioxidant activity, alpha lipoic acid helps the body utilize glucose, hence alpha lipoic acid’s potential role in improving blood sugar control. Lipoicacid is readily absorbed from the diet or as a supplement.Alpha lipoic acid increases or maintains levels of other antioxidants including COQ 10, Vitamin C, Vitamin E and glutathione, which often decline with age. As they breakdown in the course of their own metabolic function,Alpha lipoic acid aids in the recycling of Vitamin C and E.It specifically increases the production of Glutathione,one of the most common and powerful antioxidants in the body, responsible for mopping up all types of toxins and free radicals. This is particularly important during periods of excessive stress or exposure to toxins.Alpha lipoic acid serves as a coenzyme in the Krebs cycle(the basic cellular energy production cycle which produces ATP) and in the production of cellular energy.The body routinely converts some alpha-lipoic acid to dihydrolipoic acid, which appears to be an even more powerful antioxidant. Both forms of lipoic acid quench peroxynitrite radicals, an especially dangerous type of free radical consisting of both oxygen and nitrogen.Peroxynitrite radicals play a role in the development of atherosclerosis, lung disease, chronic inflammation and neurological disorders.
Green Tea Extract – Standardized L-Theanine Content Green tea is high in an anti-oxidant known asepigallocatechin gallate, or EGCG for short. Findings suggest that green tea may help protect the body against certain kinds of cancer as well as heart disease. It has anti-inflammatory and antioxidant effects.Information from both animal and human studies suggest antioxidants in green tea may lower cholesterol, reduce the risk of heart disease, and aid in the control of blood pressure.Recent scientific research also suggests that green tea has potent fat-burning properties.In a study of concentrated green tea catechins, there was a dramatic increase in the production of a group of key detoxification enzymes crucial to the body’s defense against cancer-causing chemicals and other toxins.According to the study’s lead investigator, a research associate professor at the University of Arizona, the catechins were found to alter the dangerous molecules that would otherwise damage cellular DNA, thus rendering the semolecules inert. “They actually convert known carcinogensto non-toxic chemicals.”Clinical tests show that EGCG not only inhibits the growth of new cancer cells, but it kills some existing cancer cells without harming normal cells. EGCG also can inhibit the unnatural formation of blood clots, one of the leading causes of heart attacks and stroke.L-Theanine is a derivative of green tea and is responsible for the fact that tea does not produce strong nervous system stimulation despite the presence of caffeine. Ltheanine reduces both psychological and physiological stress responses, helps learning and induces relaxation,while enhancing focus. One research project found that LTheanine may help the body’s immune response when fighting infection.
L-theanine increases the calming alpha waves in the brain and is being studied for its potential benefits in Attention Deficit Disorder. It has also demonstrated blood pressure lowering effects in animal studies. It has also been shown to help lower blood lipids.The green tea extract in Ageless Xtra/Xperia contains ten milligrams of caffeine, about one ninth to one fifteenth the amount found in a cup of coffee or about one third to one fifth the amount found in a cup of tea – not enough to create any kind of stimulant.

Niacin /Niacinamide Vitamin B3 is involved in thousands of biochemical reactions in the body, and is necessary for cell respiration and the release of energy from carbohydrates,fats and proteins. In addition, niacin supports mental function, including memory. A six year evaluation of cognitive function with healthy elderly subjects age 66 to90 demonstrated a significant association between niacin levels and certain brain functions related to learning.Niacin helps increase healthy lipids and control overall cholesterol levels.
P5P/B6Vitamin B6 is extensively involved in the metabolism of amino acids, lipids and nucleic acids. The benefits of vitamin B6 are wide ranging – from supporting protein metabolism and muscle growth to overcoming premenstrual symptoms and depression by encouraging the production of ‘feel-good’ chemicals, such as serotonin and dopamine that help maintain emotional balance.It is important to be aware that vitamin B6 comes in different forms and the type found in most multivitamin supplements is an inactive and cheaper form calledpyridoxine hydrochloride, rather than the active form:pyridoxal-5-phosphate (P5P). Certain deficiencies or liver problems can inhibit the transformation of pyridoxine to P5P and lead to nerve damage over time. P5P helps control homocysteine levels that in turn helps prevent cardiovascular disease, stroke and arthritis. Scientists from the Department of Neurology, Massachusetts General Hospital in the US, have found that levels of P5P in stroke patients is about half that of healthyindividuals. Having low P5P levels has been shown to increase the risk of stroke by up to four-fold. Low levels of P5P are significantly implicated in cases of rheumatoid arthritis as discovered by scientists at Tuft’sUniversity.
COQ10 (Xperia) Co-Enzyme Q10 (CoQ10) is an essential factor in the production of cellular energy in the mitochondria. It is also a powerful fat-soluble antioxidant. Extensive research demonstrates that CoQ10 supports healthy cardiovascular function. CoQ10 affords protection against fatty acid oxidation, which is a pivotal step in atherosclerosis. CoQ10 keeps other antioxidants (e.g. vitamins E and C) in their active states, a feature that we also saw with AlphaLipoic Acid. The amount of CoQ10 in Xperia is not a therapeutic dose. In other words, research based treatments with CoQ10 utilize much higher potencies. The dose in Xperia is supplemental only.
Chromium picolinate (Xperia) Helps maintain blood sugar levels and promotes the body’s ability to build muscle. More than 90% of U.S. adults have a deficiency of the mineral chromium. Chromium is believed to enhance insulin sensitivity, vital for the processing of glucose. The role of insulin is to usher glucose into the cells for breakdown into energy. The use of chromium as a supplement reduces blood glucose levels.High levels of glucose in the blood stream for longer periods of time leads to decreased sensitivity to insulin. This then leads to glycation, where glucose molecules bind to and damage proteins. This is a leading cause of hardening of the arteries, as these glucose protein complexes (Advanced Glycation End-products) lay down in arterial tissue. This protein damage is the principal reason that diabetics have a lower life expectancy than normal. Many researchers believe that supplement arychromium could be very useful for diabetics, especially those with type 2, or adult-onset, diabetes by encouraging glucose metabolism.Chromium polynicotinate is more effective than any other type of chromium, as it binds the elemental chromium to niacin (vitamin B-3). This provides a biologically active form of chromium that is safe and highly bio available.
Folate (Xperia) Folate helps produce and maintain new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to make DNA and RNA, the building blocks of cells. It also helps protect DNA. Both adults and children need folate to make normal red blood cells and prevent anemia. Folate is also essential for the metabolism of homocysteine, which is important because high levels of homocysteine are associated with damage to arteries and increased cardiovascular risk, atherosclerosis, etc. At least one study has linked low dietary folate intake with an increased risk of coronary events.Methylation is the passing of a chemical fragment called amethyl group (a carbon atom linked to three hydrogen atoms)from one molecule to another. This acts as an all-important signal and structural modifier throughout our bodies. DNA itself requires methylation and in animals, DNA methylationis lost with age.Folate provides the requirements for methylation of a wide variety of essential biological substances, including phospholipids, proteins, DNA, and neurotransmitters.A landmark research study at the University of Wageningen,Netherlands and published in The Lancet, showed that high dose folic acid supplements take over a long period slows the effects of aging on the brain, and “tests showed performance on memory and speed of thinking tasks was comparable to that of people five years younger


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